A relational linear program RLP is a declarative LP template defining the objective and the constraints through the logical concepts of objects, relations, and quantified variables. This allows one to express the LP objective and constraints relationally for a varying number of individuals and relations among them without enumerating them. Together with a logical knowledge base, effectively a logic program consisting of logical facts and rules, it induces a ground LP. This ground LP is solved using lifted linear programming. That is, symmetries within the ground LP are employed to reduce its dimensionality, if possible, and the reduced program is solved using any off-the-shelf LP solver. In contrast to mainstream LP template languages such as AMPL, which features a mixture of declarative and imperative programming styles, RLP’s relational nature allows a more intuitive representation of optimization problems, in particular over relational domains. We illustrate this empirically by experiments on approximate inference in Markov logic networks using LP relaxations, on solving Markov decision processes, and on collective inference using LP support vector machines. Previous article in issue.
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Obetrol , a pharmaceutical mixture of amphetamine and methamphetamine salts, was medically indicated and marketed for treating obesity , as illustrated in this advertisement from Nathanson, a Los Angeles physician, in Newspaper reports described dancers emerging from clubs at 5 a. Andrew Wilson argues that for a significant minority, “amphetamines symbolised the smart, on-the-ball, cool image” and that they sought “stimulation not intoxication [ Dick Hebdige argues that mods used amphetamines to extend their leisure time into the early hours of the morning and as a way of bridging the gap between their hostile and daunting everyday work lives and the “inner world” of dancing and dressing-up in their off-hours.
The ban is enforced through periodic drug-testing. However, the MLB has received some criticism because the consequences for amphetamine use are dramatically less severe than for anabolic steroid use, with the first offense bringing only a warning and further testing. This use sometimes continues after the student graduates college due to its addictive properties. Many felt drug use was necessary to perform adequately.
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In fact, think of your first test as a trial run, one where you learned valuable things about the test and about how you functioned under pressure. Did you arrive a little late to the testing center? Did you not have enough snack did you eat too much of your snack? Whatever it may be, think of ways you can avoid this during the retake.
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Climate change is shrinking the areas where they can live. But what if those same people who believe they are somehow immune from harm were told climate change is being blamed for the demise of an adorable, fuzzy, innocent creature? Things, perhaps, just got personal. In this corner of the country, the American pika has entirely disappeared and gone elsewhere, and researchers are saying this is the largest area of pika extirpation—vanishing from a particular area while existing elsewhere—ever reported.
In winter, rather than hibernate, they amass haypiles and use their fur to stay warm and burrow into the snow. Over the course of six years to , researchers scouted the area for pika scat and other signs of activity. Stewart forecasts a roughly 97 percent decline in pika numbers by if current trends persist in the Lake Tahoe area. There is some good news: American pikas tend to stick pretty close to their native habitats, which has led to the rise of many distinct populations around the country.
While pikas prefer cool, rocky, high-altitude environments, Erik Beever, of the U. These habitats may be both cool enough during summer and offer a buffer against bitter winter temperatures. Beever also found that pika populations, like those in the Columbia River Gorge, have supplement their diet of hay with mosses, which lets them focus on other activities during summer other than building a hay stockpile.
While the Lake Tahoe pika population may be in trouble, pikas in other parts of the country may fare better in an era of change.
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Abstract Background Genetic studies of populations from the Indian subcontinent are of great interest because of India’s large population size, complex demographic history, and unique social structure. Despite recent large-scale efforts in discovering human genetic variation, India’s vast reservoir of genetic diversity remains largely unexplored. Results To analyze an unbiased sample of genetic diversity in India and to investigate human migration history in Eurasia, we resequenced one kb ENCODE region in 92 samples collected from three castes and one tribal group from the state of Andhra Pradesh in south India.
Using unbiased allele-frequency spectra, we investigated the expansion of human populations into Eurasia. The divergence time estimates among the major population groups suggest that Eurasian populations in this study diverged from Africans during the same time frame approximately 90 to thousand years ago. The divergence among different Eurasian populations occurred more than 40, years after their divergence with Africans. Conclusions Our results show that Indian populations harbor large amounts of genetic variation that have not been surveyed adequately by public SNP discovery efforts.
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It was all quite amazing, and before Orion hooked up with Ross Jeffries and became his student, none of it would have been possible, just as anything similar would have been impossible for all the other brothers there that night. Jeffries had changed them.
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After ligand binding, the intracellular domain translocates to the nucleus and activates transcription factors. The Notch signaling pathway plays a central role in the development and maturation of most vertebrate organs, with pleiotropic effects depending on dose and context summary by Monet-Lepretre et al. The authors narrowed the critical region to a small interval bracketed by D19S centromerically and D19S telomerically.
The investigators constructed YAC and BAC contigs encompassing the critical region, the size of which was estimated to be approximately kb. Of the candidate transcripts identified through direct selection of cDNA, one showed strong homology with the 5-prime-coding end of the mouse Notch3 gene. They assembled a contiguous stretch of 5, bp of human NOTCH3 coding sequence that was highly homologous to its murine coding counterpart. By immunofluorescence analysis of embryonic day Processed Notch3 intracellular domain also localized to nuclei of ciliated suprabasal cells.
On the basis of an analysis of Drosophila mutants, it had been proposed by Rebay et al. Transient activation of Notch can direct commitment of adult hippocampal-derived progenitors irreversibly to astroglia. Astroglial induction by Notch signaling was shown to be independent of STAT3 , which is a key regulatory transcriptional factor when ciliary neurotrophic factor CNTF; induces astroglia.
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The executives are playing the Beer Game, a business simulation that is an institution at MIT, where management guru Jay Forrester invented it in the s; every entering class in Sloan tries it en masse at the beginning of the academic year. The Beer Game is at once simple to play, difficult to master and full of lessons. Among other things, the game illustrates the nonlinear nature of industrial and economic changes; the futility of blaming employees for problems beyond their control; and our general tendency to impose preconceived ideas on complex situations.
But the Beer Game has been a durable teaching tool because it hammers home a core element of MIT management thinking: Every aspect of business is a system. A company is a system. A supply chain, which the Beer Game mimics, is a system of smaller businesses. A factory is a system of machines and routines. And when one small part goes awry, a whole system can fail.
The game lasts for 50 rounds, each standing for one week. The team starts off with some chips on the table, representing cases of beer.